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目的 探讨补体活化片段C5b-9表达与胃腺癌发病之间的相关性?方法 运用组织芯片和免疫组织化学的方式对32例胃腺癌患者癌及癌旁组织C5b-9的表达进行检测,并用多项逻辑回归和似然比的方法对结果进行分析,评估相关性?结果 补体C5b-9的表达与胃腺癌疾病的临床分期(P=0.007)和TNM分期(P=0.005)密切相关,但与年龄?性别及转移程度等因素没有明显关联?结论 补体C5b-9或可作为临床中诊断胃腺癌疾病分期的标准,为诊断?评估及治疗胃腺癌提供理论依据?
Objective To investigate the correlation between the expression of C5b-9 and the incidence of gastric adenocarcinoma.Methods The expression of C5b-9 in 32 cases of gastric adenocarcinoma and adjacent normal tissues was detected by tissue microarray and immunohistochemistry, (P = 0.007) and TNM stage (P = 0.005), but not with the results of logistic regression and likelihood ratio. Age, gender and degree of metastasis were not significantly correlated.Conclusion Complement C5b-9 can be used as a standard in clinical diagnosis of gastric adenocarcinoma and provide a theoretical basis for the diagnosis, evaluation and treatment of gastric adenocarcinoma.