目的基于数据挖掘分析古代通便方剂的用药配伍规律。方法检索第5版《中华医典》中含通便内容的方剂,并根据纳入标准和排除标准进行筛选;在信息标准化处理后建立相应的方剂数据库;使用IBM SPSS Modeler 14.1软件对其进行分析。结果筛选出古代通便方剂共423首,分为汤、丸、散等多种剂型,涉及234味中药;大黄出现频率最高达210次,占总处方数的49.65%;频率最高的药对为大黄、蜂蜜,共出现151次;3味中药组合中出现频率最高的为大黄、麻子仁、蜂蜜,共出现56次。结论通过用药频次统计和Apriori算法模型等分析古代医籍文献中通便方剂的剂型、用药及其配伍规律,为现代临床用药及药物研发提供借鉴和参考。 Objective To analyze the law of drug compatibility of ancient laxatives based on data mining. Methods The prescriptions containing laxatives in Zhonghua Yi Dao of the 5th edition were searched and screened according to inclusion criteria and exclusion criteria. Corresponding prescription databases were established after information standardization was processed and analyzed by IBM SPSS Modeler 14.1 software. Results A total of 423 prescriptions of instant laxatives were screened and divided into various dosage forms such as soup, pill and powder, involving 234 kinds of traditional Chinese medicines. The frequency of rhubarb appeared up to 210 times, accounting for 49.65% of the total number of prescriptions. The drug with the highest frequency was Rhubarb, honey, appeared a total of 151 times; 3 flavors of Chinese medicine in the combination of the highest frequency of rhubarb, pockmarked, honey, a total of 56 times. Conclusion Through analyzing the dosage form, medication and compatibility of ancient laparoscopic prescriptions in the medical literature through frequency statistics and Apriori algorithm model, it provides a reference for the modern clinical drug and drug development.