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目的:观察分析重症急性胰腺炎患者采用早期肠内营养(EEN)和双歧杆菌三联活菌都胶囊联合治疗的临床疗效。方法:选取该院92例重症急性胰腺炎患者按照不同治疗方法随机分为对照组(常规治疗基础上加用EEN治疗)和实验组(在对照组基础上联合应用双歧杆菌三联活菌胶囊治疗),对比分析两组患者治疗情况以及治疗前后相关血液检测指标变化情况。结果:实验组患者住院时间(10.1±2.5)d明显低于对照组(14.8±3.2)d,实验组患者并发症发生率(13%)明显低于对照组(39.1%),两组差异对比均存在统计学意义(P<0.05)。两组患者治疗前WBC、TNF-α、IL-8、CRP、LDH、LPS以及AMY等各项指标并没有很大差异(P>0.05),治疗后两组患者各项指标均有所下降(P<0.05),而且实验组患者下降更为显著(P<0.05)。结论:重症急性胰腺炎患者联合应用EEN和双歧杆菌三联活菌胶囊治疗的临床效果良好,可有效改善患者的临床症状,值得大范围推广。
Objective: To observe and analyze the clinical effect of early enteral nutrition (EEN) and Bifidobacterium triple viable capsule in patients with severe acute pancreatitis. Methods: Ninety-two patients with severe acute pancreatitis in this hospital were randomly divided into control group (treated with EEN on the basis of routine treatment) and experimental group (treated with Bifidobacterium triple viable capsule on the basis of control group) according to different treatment methods ), Comparative analysis of two groups of patients with treatment and before and after treatment related blood test indicators change. Results: The hospitalization time in the experimental group was significantly lower than that in the control group (10.1 ± 2.5) d (14.8 ± 3.2) days. The incidence of complications in the experimental group was significantly lower than that in the control group (39.1%) There was statistical significance (P <0.05). There was no significant difference in WBC, TNF-α, IL-8, CRP, LDH, LPS and AMY between the two groups before treatment (P> 0.05) P <0.05), and the experimental group patients decreased more significantly (P <0.05). Conclusion: The combination of EEN and Bifidobacterium triple viable capsule in patients with severe acute pancreatitis has good clinical effect, which can effectively improve the clinical symptoms of patients and deserves wide application.