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研究探讨环境铅暴露和乳腺癌的关系,微量元素浓度作为乳腺癌诊断的标志物及在病因学中的意义。研究对象分为3组:对照组、良性肿瘤组、恶性肿瘤组;选用标本为组织及血标本;分析指标为血及组织中铅、锌、铜、铁、钙含量。结果显示,3组间血铅、锌、铁浓度有或部分有统计学意义;良、恶性肿瘤组织锌、铁、钙浓度高于瘤旁正常组织,部分有统计学意义;良性肿瘤组织铜浓度高于瘤旁正常组织,有统计学意义;仅瘤旁正常组织铅浓度与微量元素浓度间存在统计学的相关性。结果表明,铅暴露可能为乳腺癌的危险因素;微量元素浓度与乳腺癌有关并有望成为乳腺癌诊断的标志物。
To explore the relationship between environmental lead exposure and breast cancer, trace element concentrations as a marker of breast cancer diagnosis and its significance in the etiology. The subjects were divided into three groups: control group, benign tumor group and malignant tumor group; the selected specimens were tissue and blood specimen; the indexes of analysis were lead, zinc, copper, iron and calcium in blood and tissues. The results showed that the blood lead, zinc and iron concentrations in the three groups were partly or partially statistically significant. The concentrations of zinc, iron and calcium in benign and malignant tumors were higher than those in normal tissues, and some of them were statistically significant. The benign tumor tissue copper concentration Higher than the normal tissue adjacent to the tumor, with statistical significance; only normal tissue adjacent to the lead concentration and trace element concentrations were statistically significant correlation. The results show that lead exposure may be a risk factor for breast cancer; trace element concentrations associated with breast cancer and is expected to become a marker of breast cancer diagnosis.