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目的 进一步探讨血清前列腺特异性抗原(PSA)与前列腺增生症(BPH)之间的关系及PSA 在BPH诊断中的意义。方法 对有排尿障碍并经病理检查证实的BPH患者58例进行了分析研究。结果 72.41％的患者血清 PSA值<10ng/ml,且各年龄段 PSA值均略高于正常参考范围,但与年龄无相关关系(P>0.05)。44例开放切除术标本每克增生组织产生的 PSA值为 0.21ng/ml,60.09％的腺体重量<50g,PSA 与腺体重量的增加有一定的正相关关系(P<0.05)。本组病理检查除BPH 外,还有48.82％患者伴发有癌前病变。结论 BPH 病例血清PSA值虽略有增高,但由于多种因素的干扰,PSA失去临床诊断价值。PSA 的实际意义在于鉴别和早期发现局限性癌,与癌前病变无相关关系。
Objective To explore the relationship between serum PSA and BPH and the significance of PSA in the diagnosis of BPH. Methods 58 patients with voiding dysfunction and pathologically confirmed BPH were analyzed. Results Serum PSA levels of 72.41% of patients were less than 10ng / ml, and the PSA values of all age groups were slightly higher than the normal reference range, but no correlation with age (P> 0.05). There were positive correlations between PSA and glandular weight (P <0.05). The PSA value was 0.21ng / ml per gram of gonads and the gland weight of 60.09% was less than 50g in 44 cases of open resection specimens. This group of pathological examination in addition to BPH, there are 48.82% patients with precancerous lesions. Conclusion Although the serum PSA level of BPH patients slightly increases, PSA value of clinical diagnosis is lost due to many factors. The real significance of PSA lies in the identification and early detection of localized cancers, which are not associated with precancerous lesions.