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通过研究Ｅ－钙粘附蛋白（Ｅ－ＣＤ）在溃疡性结肠炎（ＵＣ）中的表达，探讨Ｅ－ＣＤ在ＵＣ发病中的作用。方法应用免疫组织化学方法，研究正常结肠和ＵＣ标本中的Ｅ－ＣＤ表达。结果正常组和ＵＣ组中Ｅ－ＣＤ水平无显著性差异（Ｐ＞０．０５）：ＵＣ组中Ｅ－ＣＤ表达与病情程度不相关（Ｐ＞０．０５）。结论Ｅ－ＣＤ在ＵＣ进展阶段不起主要作用，Ｅ－ＣＤ在ＵＣ触发阶段的作用尚须进一步研究。
To investigate the role of E-CD in the pathogenesis of UC by studying the expression of E-cadherin (E-CD) in ulcerative colitis (UC). Methods Immunohistochemical methods were used to study E-CD expression in normal colon and UC specimens. Results There was no significant difference in E-CD level between normal group and UC group (P> 0.05). The expression of E-CD in UC group was not correlated with the severity of disease (P> 0.05). Conclusions E-CD can not play a major role in the progression of UC. The role of E-CD in UC stage needs to be further studied.