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To explore mechanism and protective effect of rosiglitazone on myocardial ischemia reperfusion(I/R) injury.Methods:A total of 48 male Japanese white big-ear rabbits were randomly divided into control group(A),I/R group(B),low dose of rosiglitazone group(C),high dose of rosiglitazone group(D).Plasma concentration of and also reduced the concentration of plasma serum creatine kinase(CK),CK-MB.high-sensitivity C-reactive protein(hsCRP).ultrasuperoxide dismutase(SOD),malondialdehyde(MD.A).lactic acid glutathione skin peroxidase (C-SH-PX).nitric oxide(NO)and endothelin(ET) were measured 1 h later after I/R.Twenty-four hours after I/R the hearts were harvested for pathological and ultrastructural analysis.Area of myocardial infarction were tested.Results:Plasma concentration of CK,Ck-MB.hsCRP,NO. MDA and ET were decreased in C,D group compared with group B.Plasma concentration of T-SOD and GSH-Px were increased significantly in C.D group compared with group B.Compared with group B.pathological and ullraslructural changes in C and D group were slightly.There was significant difference in myocardial infarction area between group C.D and group B(P<0.05). Myocardial infarction area and arrhythmia rate were lower in group C,D compare with group B. Rosiglitazone may protect myocardium from I/R injury by enhancing T-SOD and GSH-Px concentration,inhibit inflammatory reaction,and improve endothelial function.
To explore mechanism and protective effect of rosiglitazone on myocardial ischemia reperfusion (I / R) injury. Methods: A total of 48 Japanese Japanese white big-ear rabbits were randomly divided into control group (A), I / R group low dose of rosiglitazone group (C), high dose of rosiglitazone group (D). Plasma concentration of and also reduced concentration of plasma serum creatine kinase (CK), CK-MB high-sensitivity C-reactive protein (hsCRP). (C-SH-PX) .nitric oxide (NO) and endothelin (ET) were measured for 1 h later after I / R. Twenty-four hours after I / R the hearts were harvested for pathological and ultrastructural analysis. Area of myocardial infarction were tested. Results: Plasma concentration of CK, Ck-MB. hsCRP, NO. MDA and ET were decreased in C, D group compared with group B .Plasma concentration of T-SOD and GSH-Px were increased significantly in CD group compared with group B.Compared with group B.pathologic al and ullraslructural changes in C and D group were slightly slightly in myocardial infarction area between group CD and group B (P <0.05). Myocardial infarction area and arrhythmia rate were lower in group C, D compare with group B. Rosiglitazone may protect myocardium from I / R injury by enhancing T-SOD and GSH-Px concentration, inhibit inflammatory reaction, and improve endothelial function.