目的为了解上海浦东新区某社区老年居民对原发性骨质疏松症(PO,Primary Osteoporosis)的认知情况,评价社区综合干预措施的效果。方法选取该社区160例50岁以上的在2014年2~5月被诊断为PO的患者,随机分为对照组和社区综合干预组,随访1年。1年内定期监测骨源性碱性磷酸酶(NBAP)、尿钙/肌酐(Ca/Cr)、骨密度(BMD)和福善美药物占有率(MPR)。结果 83.70%的患者对PO认识不足,无日常防治措施。与基线值及同期对照组相比,干预组患者1年后的NBAP和BMD明显增高,尿Ca/Cr明显降低(P<0.05)。与基线值相比,对照组1年后的NBAP、BMD降低,尿Ca/Cr增高(P<0.05)。干预组的MPR较同期对照组明显改善(P<0.05)。结论社区综合干预措施能明显提高居民对骨质疏松症的认识,可有效避免骨质疏松症所带来的骨折等并发症,改善老年居民生活质量。 Objective To understand the cognition of primary Osteoporosis in elderly residents in a community in Pudong New Area, Shanghai, and to evaluate the effect of community-based interventions. Methods A total of 160 patients over 50 years old who were diagnosed as PO from February to May 2014 in the community were selected and randomly divided into control group and community comprehensive intervention group, followed up for 1 year. Periodic monitoring of bone alkaline alkaline phosphatase (NBAP), urinary calcium / creatinine (Ca / Cr), bone mineral density (BMD) and Fosamax drug possession (MPR) were monitored over a period of one year. Results 83.70% of patients did not know enough about PO, and no routine prevention and treatment measures were taken. Compared with the baseline value and the control group, NBAP and BMD in the intervention group were significantly increased and the urinary Ca / Cr significantly decreased (P <0.05). Compared with baseline, NBAP, BMD and urine Ca / Cr in control group decreased after one year (P <0.05). The intervention group MPR than the control group was significantly improved (P <0.05). Conclusion Comprehensive community intervention can significantly improve residents’ understanding of osteoporosis, effectively avoid complications such as osteoporosis caused by osteoporosis, and improve the quality of life of elderly residents.