目的 :探讨脐动脉彩色多普勒血流频谱分析在胎儿畸形中的临床意义。方法 :1997年 10月至 1999年 11月于本院行彩色多普勒超声检查胎儿发育异常 5 9例 ,全部病例在出生或引产后得到证实。同期收集正常孕妇 15 4例作为对照组 ,研究其脐动脉血流收缩期峰速与舒张期末期最低速度之比值 (S/ D值 )。结果 :胎儿畸形组的 S/ D值明显高于正常组 (P<0 .0 1) ;各类畸形中 ,多发畸形、消化系统畸形和中枢神经系统畸形组脐动脉血流 S/ D值异常者明显多于正常对照组 (P<0 .0 0 5 ) ;而泌尿系统畸形和胸、腹水组与正常对照组比较 ,无显著差异 (P>0 .0 1)。结论 :胎儿畸形 ,尤其是多发畸形、消化系统畸形和中枢神经系统畸形可引起 S/ D值增高。 Objective: To investigate the clinical significance of color Doppler flow spectrum analysis of umbilical artery in fetal malformation. Methods: From October 1997 to November 1999, 59 cases of fetal abnormalities were examined by color Doppler sonography in our hospital. All cases were confirmed after birth or induced abortion. During the same period, 15 4 normal pregnant women were collected as the control group to study the ratio of the peak systolic velocity to the lowest diastolic velocity (S / D) in umbilical artery blood flow. Results: S / D values ​​in fetal malformation group were significantly higher than those in normal group (P <0.01). In all kinds of malformations, abnormal S / D values ​​of umbilical artery blood flow in multiple malformation, digestive system deformity and central nervous system malformation (P <0.05). There was no significant difference in urinary malformation, thorax and ascites between the control group and the control group (P> 0.05). Conclusion: Fetal malformations, especially multiple malformations, digestive system deformities and central nervous system deformities, may cause S / D values ​​to increase.