目的　探讨血管内皮生长因子 (VEGF)在佐剂关节炎大鼠滑膜组织中的表达及其与关节病理积分关系。方法　通过右足垫皮内注射完全福氏佐剂建立关节炎大鼠模型 ,常规HE染色 ,计算关节病理积分 ,逆转录 聚合酶链反应 (RT PCR)检测VEGFmRNA表达 ,免疫组织化学染色检测VEGF蛋白表达 ,观察VEGF蛋白表达与关节病理积分关系。结果　模型组组大鼠滑膜VEGFmRNA及蛋白表达在 3、8周及 2 0周时均明显高于对照组 (P均 <0 .0 1) ,而且与关节病理积分呈正相关 (r =0 .984 ,0 .96 ,0 .92 9　P均 <0 .0 1)。结论　VEGF在关节炎形成及发展过程中起重要作用 ,可直接影响滑膜新生血管形成 Objective To investigate the expression of vascular endothelial growth factor (VEGF) in the synovial tissue of adjuvant arthritis rats and its relationship with the pathological score. Methods Arthritis rat model was established by intradermal injection of complete Freund’s adjuvant in right foot pad. The expression of VEGF mRNA was detected by routine HE staining and RT-PCR. VEGF protein expression was detected by immunohistochemical staining , Observe the relationship between VEGF protein expression and pathological score. Results The expression of VEGFmRNA and protein in synovial membrane of model group were significantly higher than that of control group at 3, 8 and 20 weeks (all P <0.01), and positively correlated with pathological score (r = 0.984, 0 .96, 0.92 9 P <0.01). Conclusion VEGF plays an important role in the formation and development of arthritis and can directly affect synovial neovascularization