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目的:探讨黄芪、党参对妊娠期高血压疾病(PIH)患者肾功能损害的修复作用。方法:随机选取妊娠期高血压疾病子痫前期孕妇102例,分为对照组和观察组;对照组给予常规硫酸镁治疗,观察组给予硫酸镁+中药黄芪、党参治疗。分别测定用药后对照组、观察组24 h尿蛋白定量、血β2-MG、脐血流S/D等指标变化的幅度。结果:治疗后观察组24 h尿蛋白定量、β2-MG、脐血流S/D及收缩压降幅均较对照组明显,差异有统计学意义(P<0.05);对照组和观察组比较舒张压下降不明显(P>0.05)。结论:中药黄芪、党参对妊娠期高血压疾病患者肾功能损害有明显修复作用。
Objective: To investigate the repair effect of Astragalus and Codonopsis on renal dysfunction in patients with hypertensive disorders of pregnancy (PIH). Methods: 102 cases of pregnant women with preeclampsia of pregnancy-induced hypertension were randomly divided into control group and observation group. The control group was given conventional magnesium sulfate treatment. The observation group was given magnesium sulfate + traditional Chinese medicine astragalus and Codonopsis. The changes of 24 h urinary protein, blood β2-MG and S / D of umbilical blood flow in control group and observation group were measured respectively after treatment. Results: After 24 h of treatment, urinary protein, β2-MG, S / D of umbilical blood flow and systolic pressure drop of 24 h in observation group were significantly higher than those in control group (P <0.05); compared with those in observation group, Pressure drop was not significant (P> 0.05). Conclusion: Astragalus membranaceus and Codonopsis pilosula have obvious repairing effects on renal dysfunction in patients with hypertensive disorder complicating pregnancy.