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目的观察自体细胞因子诱导的杀伤细胞输注联合IL-2治疗老年淋巴瘤的有效性和安全性。方法 1例老年脾脏恶性淋巴瘤患者在经过手术切除脾脏原发肿瘤、8个疗程的R-CHOP方案免疫化疗后出现淋巴瘤肝脏转移,此时采集患者外周血单核细胞,在体外经干扰素-γ(IFN-γ)、白介素-2(IL-2)和抗CD3单克隆抗体诱导成CIK细胞,每次回输细胞数为2-3×109个,回输后应用IL-2 100mU/d,皮下注射,连续10d,28d为1个周期。观察治疗前后患者肝功能、肿瘤相关生物学指标及影像学变化。结果患者共完成8个周期的CIK细胞输注,每次回输后未出现不良反应,肝功能指标、LDH水平均降至正常,PET/CT检查示治疗后肝脏淋巴瘤转移灶消失,达到完全缓解。结论自体CIK细胞输注联合IL-2疗法对于清除治疗后淋巴瘤的微小残留灶和(或)转移灶安全有效。
Objective To observe the efficacy and safety of autologous cytokine-induced killer cell infusion combined with IL-2 in the treatment of elderly lymphoma. Methods One case of splenic malignant lymphoma in elderly patients undergone surgical resection of the primary tumor of the spleen and eight courses of R-CHOP chemotherapy and immunotherapy after liver metastases of lymphoma, mononuclear cells collected at this time, in vitro by interferon IL-2 (IL-2) and anti-CD3 monoclonal antibodies were induced into CIK cells, the number of reinfusion cells per injection was 2-3 × 109 cells. IL-2 100mU / d , Subcutaneous injection, continuous 10d, 28d for a cycle. Observe the liver function before and after treatment, tumor-related biological indicators and imaging changes. Results A total of 8 cycles of CIK cell infusion were performed. No adverse reaction was observed after each infusion. Liver function and LDH levels were all reduced to normal. PET / CT showed disappearance of metastatic liver lymphoma and complete remission . Conclusions Autologous CIK infusion combined with IL-2 therapy is safe and effective in removing minimal residual tumor and / or metastasis of lymphoma after treatment.