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目的研究甲氨蝶呤和地塞米松注射关节内改善类风湿患者的膝关节功能。方法选取2014年1月—2017年1月该院收治的820例类风湿关节炎患者,运用随机方法分为研究组和对照组各410例,对照组采用地塞米松注射液5 mg注入膝关节腔内。研究组则对照组治疗的基础上联合甲氨蝶呤进行治疗。结果治疗后两组患者的膝关节功能指标均明显进步(P<0.05);研究组患者的总有效率(99.5%)显著高于对照组(48.7%),差异有统计学意义(P<0.05)。结论关节内注射甲氨蝶呤和地塞米松有效改善类风湿患者膝关节功能,减少关节损伤,身体各项机能有效改善,患者的生活质量也有效提升,临床上值得推广应用。
Objective To study the effects of methotrexate and dexamethasone on the knee joint in rheumatoid arthritis patients. Methods A total of 820 rheumatoid arthritis patients admitted to our hospital from January 2014 to January 2017 were randomly divided into study group (410 cases) and control group (410 cases). The control group was injected with 5 mg dexamethasone injection into the knee joint Cavity. The study group was treated with methotrexate on the basis of the control group. Results After treatment, the knee joint function indexes of both groups were significantly improved (P <0.05). The total effective rate (99.5%) in the study group was significantly higher than that in the control group (48.7%), the difference was statistically significant (P <0.05 ). Conclusion Intra-articular injection of methotrexate and dexamethasone can effectively improve knee joint function and reduce joint damage in rheumatoid arthritis patients. The body functions are effectively improved and the quality of life of the patients is effectively improved. Therefore, it is clinically worthy of promotion and application.