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顶复门寄生虫入侵宿主细胞的能力是其生存和致病的关键。刚地弓形虫(Toxoplasma gondii)是顶复门的一种专性细胞内寄生虫,无论其滑行、入侵或逸出感染细胞,都必须依靠被称为肌-动球蛋白马达(actomyosin motor,AMM)的装置提供动力。AMM主要由肌球蛋白A、1条肌球蛋白轻链(myosin light chain,MLC1)和2条必需轻链(essential light chain,ELC)1、2以及滑行相关蛋白(gliding-associated protein,GAP)组成。目前已经发现的GAP家族包括GAP45、GAP50、GAP80、GAP70和GAP40,它们是构成驱动寄生虫运动的滑行体的重要成分。滑行体是一个存在于寄生虫质膜与内膜复合物之间的以肌-动球蛋白为基础的动力装置。本文概述了目前对GAP构建与功能的理解以及弓形虫运动的分子基础,同时对GAP作为弓形虫病疫苗候选抗原分子作了展望。
The ability of apicocerans to invade host cells is the key to their survival and pathogenicity. Toxoplasma gondii, a potent intracellular parasitoid of the apicocera, must glide, invade or escape from infected cells by virtue of the so-called actomyosin motor (AMM ) Of the device to provide power. AMM is mainly composed of myosin A, myosin light chain (MLC1) and two essential light chains (ELCs) 1, 2 and gliding-associated protein (GAP) composition. The GAP families that have been discovered so far include GAP45, GAP50, GAP80, GAP70 and GAP40, which are important components of the taxa that constitute the parasites that drive parasites. The gliding body is a muscle-actin-based motive device that exists between the parasite plasma membrane and the intima-complex. This article provides an overview of the current understanding of GAP construction and function as well as the molecular basis of Toxoplasma gondii movement, and looks forward to GAP as a candidate antigen candidate for the vaccine against toxoplasmosis.