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目的评估“粉尘螨滴剂”治疗儿童过敏性哮喘的有效性及依从性。方法对符合儿童过敏性哮喘诊断标准并且粉尘螨变应原皮肤点刺试验呈阳性的136人分为两组,对照组(54人)给予吸入糖皮质激素治疗,舌下含服组患儿在吸入糖皮质激素治疗的基础上加舌下含服“粉尘螨滴剂”进行脱敏治疗。结果含服“粉尘螨滴剂”的患儿,血清螨SIgE在用药后3个月时下降并持续到12个月,治疗12个月时肺功能FEV1明显改善,咳嗽发作次数减少,哮喘发作次数、频率均减少,末发现不良反应。舌下含服组与对照组SIgE、FEV1在治疗12个月时相比,P值均<0.05。结论 “粉尘螨滴剂”免疫疗法作为吸入激素的辅助疗法治疗儿童过敏性哮喘患儿有明显效果。
Objective To evaluate the effectiveness and compliance of “Dust Mite Drops” in treating childhood allergic asthma. Methods One hundred and fourty-six patients who were diagnosed as having allergic asthma were divided into two groups. The control group (54) received glucocorticoid injections. The sublingual group Inhaled glucocorticoid treatment based on the sublingual sublingual “dust mite drops” for desensitization treatment. Results Serum mite SIgE decreased 3 months after administration and lasted for 12 months in children with “Dust Drops”. After 12 months of treatment, pulmonary function FEV1 was significantly improved, the number of cough seizures was reduced, and asthma The number of seizures, the frequency was reduced, the end found adverse reactions. Compared with SIgE and FEV1 in the sublingual group and the control group, the P values were all <0.05 at 12 months. Conclusion “dust mite drops ” immunotherapy as an adjunct to inhaled hormones in children with allergic asthma have a significant effect.