自从1785年引入洋地黄作为强心药治疗充血性心力衰竭以来,至今已有近200年的历史。目前,洋地黄仍是治疗心力哀竭最重要的药物。但洋地黄的最大缺点是治疗安全系数小,治疗量约为中毒量的60%,特别是心脏的毒性,往往是应用洋地黄的主要障碍。为此,百多年来世界各地的科学家努力去寻找更好的 Nearly 200 years have passed since the introduction of digitalis in 1885 as a cardiotonic for the treatment of congestive heart failure. At present, digitalis is still the most important drug for the treatment of heart failure. However, the biggest drawback of digitalis is the treatment of small safety factor, the amount of treatment is about 60% of the amount of poisoning, especially the toxicity of the heart, often the main obstacle to the application of digitalis. For this reason, scientists from all over the world have worked hard for more than a hundred years