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It has been shown that most human genes are alternatively spliced and defects in alternative splicing(AS)contribute to cancer[1,2]. However,currently,antibody microarrays are not used to study alternative splicing,which enhances proteome diversity and also modulate cancer-related proteins[2~4]. Here we present an approach that allows the generation of an antibody microarray for the analysis of the expression of splice variants associated with cancer. It is based on transcriptional profiling experiments of DNA-microarrays and other results,100 splice
It has been been shown that most human genes are alternatively spliced and defects in alternative splicing(AS)contribute to cancer[1,2]. However, current, antibody microarrays are not used to study alternative splicing, which enhances proteome diversity and also modulate cancer -related proteins[2~4]. Here we present an approach that allows the generation of an antibody microarray for the analysis of the expression of splice variants associated with cancer. It is based on transcriptional profiling experiments of DNA-microarrays and other results, 100 splice