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目的:观察常规体外受精和卵胞浆内单精子注射两种不同体外受精方式对胚胎玻璃化冷冻复苏的影响。方法:将移植冷冻复苏胚胎的患者(均为玻璃化法)分为两组。IVF组:新鲜周期采取常规体外受精方式而获得的胚胎;ICSI组:新鲜周期采取卵胞浆内单精子注射方式受精而得到的胚胎;比较两组的不孕类型、不孕原因以及冷冻复苏周期的复苏率、着床率、临床妊娠率和流产率等。结果:IVF组和ICSI组的复苏率、着床率、临床妊娠率差异无统计学意义(P>0.05),ICSI组的流产率明显高于IVF组但差异无统计学意义(P>0.05),IVF组和ICSI组原发不孕所占比例、继发不孕所占比例差异有统计学意义(P<0.05),IVF组和ICSI组男方因素不孕所占比例、输卵管因素不孕所占比例差异有统计学意义(P<0.05)。结论:ICSI不影响胚胎玻璃化冷冻周期的复苏率、着床率及临床妊娠率,ICSI后胚胎玻璃化冷冻复苏流产率有升高的趋势,ICSI体外受精方式主要用于原发不孕患者以及男方因素导致的不孕患者。
OBJECTIVE: To observe the effect of two different in vitro fertilization methods, including in vitro fertilization and intracytoplasmic sperm injection on embryo vitrification. Methods: All patients (all vitrified) with frozen-thawed embryos were divided into two groups. IVF group: embryos obtained by routine in vitro fertilization in fresh cycle; ICSI group: embryos obtained by fertilization by intracytoplasmic sperm injection in fresh cycle; infertility type, reason of infertility and cycle of cryotherapy and resuscitation Recovery rate, implantation rate, clinical pregnancy rate and abortion rate. Results: The recovery rate, implantation rate and clinical pregnancy rate in IVF group and ICSI group were not significantly different (P> 0.05). The abortion rate in ICSI group was significantly higher than that in IVF group, but the difference was not statistically significant (P> 0.05) , The proportion of primary infertility in IVF group and ICSI group was significantly higher than that in secondary infertility group (P <0.05), the proportion of male infertility in IVF group and ICSI group, the incidence of infertility in tubal factor The difference was statistically significant (P <0.05). CONCLUSION: ICSI does not affect the recovery rate, implantation rate and clinical pregnancy rate of embryo vitrification cycle. The ICSI rate of embryo vitrification and thawing has a rising trend. ICSI IVF is mainly used in primary infertility patients and Male factor causes infertility patients.