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目的 探讨先天性心脏病 (先心病 )肺动脉高压病儿血浆内皮素 1(ET 1)和胶原增生的相互关系及其在先心病肺动脉高压形成中的作用。方法 2 0例左向右分流型先心病病儿分为肺动脉高压组(PH组 )和无肺动脉高压组 (对照组 ) ,用放射免疫学方法测定两组病儿血浆ET 1水平 ,用SDS 间断聚丙烯酰胺凝胶电泳 (SDS PAGE)测定肺组织I、III型胶原含量。结果 与对照组相比 ,PH组血浆ET 1水平和肺组织I、III型胶原含量明显增加 (P <0 0 1)。PH组血浆ET 1水平与肺组织I、III型胶原含量呈显著正相关。结论 先心病肺动脉高压的形成可能与ET 1水平升高 ,诱导肺组织I、III型胶原增生有关。
Objective To investigate the relationship between endothelin 1 (ET 1) and collagen hyperplasia in children with congenital heart disease (CHD) and its effect on pulmonary hypertension. Methods Twenty cases of left-right shunt congenital heart disease were divided into two groups: pulmonary hypertension group (PH group) and non-pulmonary hypertension group (control group). Plasma ET 1 levels were measured by radioimmunoassay in both groups. Polyacrylamide gel electrophoresis (SDS PAGE) lung tissue I, III collagen content. Results Compared with the control group, the levels of plasma ET 1 and the levels of type I and type III collagen in lung tissue in PH group were significantly increased (P <0.01). Plasma ET 1 level in PH group was positively correlated with the content of collagen type I and III in lung tissue. Conclusions The formation of pulmonary hypertension in congenital heart disease may be related to the increase of ET 1 level and the induction of type I and III collagen hyperplasia in lung tissue.