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胃粘膜损伤模型的测试:给药组动物预先给补中益气汤煎剂,3h 后分别灌服无水乙醇、0.6mol/LHCl,0.2mol/LNaOH、消炎痛,后处死动物,观察胃粘膜损伤情况。胃壁结合粘液测定:给大鼠灌服补中益气汤,每日1次,连续3次,后取胃测胃壁结合粘液含量。胃组织 PGE_2含量测定:动物给药后处死,剪取胃腺部组织一块,按 PGE_2放免药盒法测定。结果:(1)灌服乙醇等后,大鼠胃粘膜明显损伤,其腺胃部呈条索状出血性损伤,而给药组能
Gastric mucosal injury model test: Animals in the administration group were given Buzhong Yiqi Decoction in advance. After 3 hours, ethanol, 0.6 mol/L HCl, 0.2 mol/L NaOH, and indomethacin were given respectively. After the animals were sacrificed, gastric mucosa was observed. Damage situation. Gastric wall combined with mucus determination: The rats were fed Buzhong Yiqi Decoction once a day for 3 consecutive times, and then the stomach was taken to measure the content of mucus in the stomach wall. The content of PGE 2 in gastric tissue was determined after animals were sacrificed, and a piece of gastric gland tissue was cut out and measured by PGE 2 release kit method. Results: (1) After oral administration of ethanol, rats’ gastric mucosa was significantly damaged, and the glandular stomach showed cord-like hemorrhagic injury.