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目的:评价引导组织再生术(GTR)在错牙合畸形伴牙周病患者治疗中的应用价值.方法:共纳入68例患者,随机分为对照组和实验组,每组34例.对照组:进行正畸和牙周病治疗;实验组:治疗的同时应用GTR(Bio-Oss骨胶原联合Bio-Gide胶原膜),对比治疗后6个月患者的正畸疗效,治疗前、治疗后1个月和6个月的牙周指标包括探诊深度(PD)、附着丧失(AL)、牙龈退缩(GR)和骨密度值.结果:实验组的正畸疗效明显优于对照组,差异有统计学意义(P0.05),实验组PD、AL和GR值进一步降低,骨密度值升高(P0.05), the values of PD, AL and GR in the experimental group were further decreased and the bone mineral density were further increased (P<0.05), and there was significant difference between the control group and the experimental group (P<0.05). Conclusion GTR can further improve the short-term effect of orthodontic treatment and periodontal repairment in patients with malocclusion and periodontal disease.