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目的探讨胶原诱导性关节炎(collagen-induced arthritis,CIA)大鼠滑膜组织膜联蛋白-1 (Annexin-1)的表达及意义。方法采用Western blot法检测模型组及正常组大鼠在不同时间点滑膜组织Annexin-1的表达,运用ImageTool 3．0灰度扫描软件对结果进行半定量分析。结果正常组及模型组皆表达Annexin-1。模型组Annexin-l表达在25、35和45d水平递减,45d与25d相比,差异有统计学意义(P＜0．05)。45d Annexin-1表达明显低于正常组(P＜0．05)。结论CIA大鼠滑膜组织Annexin-1表达下调。
Objective To investigate the expression of Annexin-1 in synovial tissue of collagen-induced arthritis (CIA) rats and its significance. Methods Western blot was used to detect the expression of Annexin-1 in synovial tissue of rats in model group and normal group at different time points. The results were semi-quantitatively analyzed by ImageTool 3.0 gray-scale scanning software. Results Annexin-1 was expressed in both normal and model groups. The expression of Annexin-1 in model group decreased at 25, 35 and 45 d, and the difference was statistically significant at 45d and 25d (P <0.05). 45d Annexin-1 expression was significantly lower than the normal group (P <0.05). Conclusions The expression of Annexin-1 in synovial tissue of CIA rats is down-regulated.