流行病学调查显示,约20%~50%的糖尿病患者合并有自主神经病变(CAN),其中心脏自主神经病变是最严重的并发症之一[1]。研究报道,CNA在1型糖尿病患者中的发病率为17%,在2型糖尿病患者中的发病率为22%。临床表现为运动耐受性不良,直立性低血压,严重出现静息持续性窦性心动过速,无症状性心肌缺血,无痛性心肌梗死,甚至心脏性猝死等[2-3]。很多流行病学资料表明[3-4],5 Epidemiological survey shows that about 20% to 50% of diabetic patients with autonomic neuropathy (CAN), of which autonomic neuropathy is one of the most serious complications [1]. The study reported a CNA incidence of 17% in patients with type 1 diabetes and 22% in patients with type 2 diabetes. Clinical manifestations of poor motor tolerance, orthostatic hypotension, severe continuous resting sinus tachycardia, asymptomatic myocardial ischemia, painless myocardial infarction, and even sudden cardiac death [2-3]. A lot of epidemiological data show that [3-4], 5