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目的观察确诊为原发小儿癫痫症患儿的临床症状表现以及脑电图特征,探讨有效的治疗方法。方法 28例原发小儿癫痫症患儿,采用单盲法对其进行治疗,10例应用单一丙戊酸钠进行治疗(A组),9例应用单一托吡酯进行治疗(B组),9例应用托吡酯联合左乙拉西坦进行治疗(C组)。比较临床疗效。结果 A组的平均治疗时间为(14.23±2.36)个月,其中,完全缓解(CR)8例、部分缓解(PR)1例、稳定(SD)1例,疾病控制率为90.00%;B组的平均治疗时间为(15.42±2.46)个月,其中,CR 7例、PR 2例、SD0例,疾病控制率为95.56%;C组的平均治疗时间为(14.65±2.12)个月,其中,CR 8例、PR 1例、SD 0例,疾病控制率为97.78%。三组治疗时间及疾病控制率比较差异无统计学意义(P>0.05);复查肝功能,A组出现2例肝功能损害,B组出现1例,未进行特殊治疗仅停药3个月其肝功能均恢复;随访2~3年,远期有效率为96.43%。结论为原发小儿癫痫症患儿单一应用丙戊酸钠或托吡酯药物进行治疗,在必要的情况下应用托吡酯联合左乙拉西坦药物进行治疗,并密切观察患儿的肝功能情况,保证用药合理,有利于提高疗效。
Objective To observe the clinical manifestations and EEG features of children diagnosed with primary pediatric epilepsy and to explore effective treatment. Methods 28 children with primary epilepsy were treated by single blinded method, 10 cases were treated with sodium valproate alone (group A), 9 cases were treated with topiramate (group B), and 9 cases were used Topiramate combined with levetiracetam (group C). Compare clinical curative effect. Results The mean duration of treatment in group A was (14.23 ± 2.36) months, of which 8 were complete remission (CR), 1 was partial remission (PR), 1 was stable (SD) and the disease control rate was 90.00% (15.42 ± 2.46) months, of which CR 7 cases, PR 2 cases and SD 0 cases, the disease control rate was 95.56%; the average treatment time in group C was (14.65 ± 2.12) months, of which, CR 8 cases, PR 1 cases, SD 0 cases, the disease control rate was 97.78%. Three groups of treatment time and disease control rate difference was not statistically significant (P> 0.05); review of liver function, A group of two cases of liver dysfunction, B group appeared in 1 case, without special treatment only for 3 months Liver function were recovered; follow-up of 2 to 3 years, the long-term effective rate was 96.43%. Conclusions: The children with primary pediatric epilepsy were treated with sodium valproate or topiramate alone, topiramate combined with levetiracetam should be used when necessary, and the liver function of the children should be closely monitored to ensure the medication Reasonable, help to improve the curative effect.