血管能抑素是最新发现的一种内源性血管抑制因子,来源于IV型胶原。实验证明其在体外能显著抑制血管内皮细胞的增生和迁移,诱导其凋亡,在体内能抑制肿瘤新生血管生成。血管能抑素作为抗血管生成治疗的新策略,在眼科基因治疗方面有很好的应用前景,尤其是视网膜新生血管。本文就血管能抑素的发现、命名、生物学特性、作用机制及在眼科应用前景作一综述。 Angiostatin is the newly discovered endogenous vascular inhibitory factor, derived from type IV collagen. Experiments show that it can significantly inhibit vascular endothelial cell proliferation and migration in vitro, induce apoptosis, in vivo can inhibit tumor angiogenesis. As a new strategy of anti-angiogenic therapy, angiostatin has a good prospect in the field of ophthalmic gene therapy, especially retinal neovascularization. This review summarizes the discovery, nomenclature, biological characteristics, mechanism of action and prospects in ophthalmology of angiostatin.