速尿是一种强力利尿剂,但由于其作用机理所致,在治疗期间亦可引起严重生化异常和临床反应。常见重要的不良反应是电解质异常、失水伴氮质血症或/和低血压。本文报道一项前瞻性研究以确定速尿诱致上述改变的发生率及其诱因。作者报道204例接受速尿的住院患者(男122例、女82例,平均年龄69.6岁)的临床和实验室资料。明确或可能由药物诱致的生化异常和临床并发症分别发生于70.6%和49.0%的患者,归咎于速尿者分别为其中的81.3%和13.0%。最重要的临床并发症是失水和 Furosemide is a potent diuretic, but due to its mechanism of action, it can also cause serious biochemical abnormalities and clinical reactions during treatment. Common adverse reactions are electrolyte abnormalities, dehydration with azotemia, and / or hypotension. This article reports a prospective study to determine the incidence of furosemide-induced changes and their causes. The authors reported the clinical and laboratory data of 204 hospitalized patients (male 122, female 82, average age 69.6 years) receiving furosemide. Biochemical abnormalities and clinical complications that were clearly or potentially drug-induced occurred in 70.6% and 49.0% of patients, respectively, as 81.3% and 13.0%, respectively, of those who were diuresis. The most important clinical complication is dehydration and