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目的探讨盐酸戊乙奎醚与阿托品在小儿氯胺酮麻醉术前应用的临床效果。方法选取我院2012年9月至2013年9月所收治的30例择期手术患儿,随机分为两组,A组患儿给予氯胺酮+盐酸戊乙奎醚;B组患儿给予氯胺酮+阿托品。比较两组患儿用药前及用药后不同时间的唾液分泌量、心率(HR)、收缩压(SBP)、舒张压(DBP)的变化情况。结果两组患儿用药前唾液分泌量比较无统计学意义,但用药后唾液分泌量均明显降低,A组患儿在用药后不同时间段内其唾液分泌量均明显低于B组,说明A组患儿表现有强烈的唾液分泌抑制,差异有统计学意义(P<0.01);两组患儿用药前HR、SBP、DBP无统计学意义,用药后上述指标均较用药前有明显变化,差异有统计学意义(P<0.05),但A组患儿的变化程度明显低于B组患儿,组间比较差异有统计学意义。结论盐酸戊乙奎醚对患儿的血压、心率都具有较小的影响,也能对唾液腺分泌作用起到较为明显的抑制作用。
Objective To investigate the clinical effect of penehyclidine hydrochloride and atropine in pediatric ketamine anesthesia before operation. Methods Thirty patients undergoing elective surgery in our hospital from September 2012 to September 2013 were randomly divided into two groups. Group A was given ketamine + penehyclidine hydrochloride; Group B was given ketamine + atropine . The changes of salivary secretion, heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared between the two groups before and after treatment. Results There was no significant difference in salivary secretion before treatment in both groups, but salivary secretion was significantly decreased after treatment. The salivary secretion in group A was significantly lower than that in group B at different time points after treatment, indicating that A There was a strong inhibition of salivary secretion in the children (P <0.01). There was no significant difference in HR, SBP and DBP before treatment between the two groups. After treatment, the above indexes were significantly changed compared with those before treatment, The difference was statistically significant (P <0.05), but the changes in group A were significantly lower than those in group B, the difference was statistically significant. Conclusion Penehyclidine hydrochloride has a small effect on blood pressure and heart rate in children, and can also significantly inhibit salivary gland secretion.