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目的:探讨江门地区女性生殖道人乳头瘤病毒感染以及HPV基因亚型的分布状况。方法:2009年1月~2010年3月采取HPV导流杂交基因芯片技术对2000名志愿者进行宫颈癌筛查,并对HPV亚型感染、多重感染及感染者年龄分布情况进行分析。结果:2000例女性HPV感染422例,平均年龄为(35.6±9.9)岁,HPV感染率为21.1%(422/2000);高危型HPV前五位排列分别为HPV16、52、58、33、53,低危型HPV前三位排列分别为HPV11、6、44;单重感染占79.3%、多重感染占20.7%;从6个年龄组中HPV感染率前三位排列是61~75岁、16~20岁、21~30岁年龄段,分别是43.6%、30.5%、24.0%,她们之间存在明显的差异(P<0.01)。结论:江门地区女性生殖道人乳头瘤病毒感染最常见的亚型为HPV16,HPV基因亚型的分布存在地方性的差异。
Objective: To investigate the distribution of human genital HPV infection and HPV genotypes in Jiangmen area. Methods: From January 2009 to March 2010, 2000 volunteers were screened for cervical cancer with HPV diversion hybridization gene chip technique. The distribution of HPV subtypes, multiple infections and age of infection were analyzed. Results: Of the 2000 women with HPV infection, 422 cases had a mean age of (35.6 ± 9.9) years and HPV infection rate was 21.1% (422/2000). The top five high-risk HPV types were HPV16,52,58,33,53 , The first three low-risk HPVs were HPV11,6,44 respectively; 79.3% were single-infection and multiple infections were 20.7%; the top three HPV infection rates in six age groups were 61-75 years old, 16 ~ 20 years old, 21 ~ 30 years of age, respectively, 43.6%, 30.5%, 24.0%, there was a significant difference between them (P <0.01). Conclusion: The most common subtype of human papillomavirus infection in female reproductive tract in Jiangmen area is HPV16. The distribution of HPV subtypes is endemic.