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由于肿瘤的乏氧状态不利于光敏杀伤癌细胞的~1O_2和·OH的生成,因此Moan等学者提出的光敏剂阴离子自由基对癌细胞可能有损伤作用的观点就很有意义。要探讨上述作用的机制,首先要搞清阴离子基的生成与氧的关系,为此,本文用ESR方法研究了卟啉类光敏药物Photofrin Ⅱ等的有效成分Dihematoporphyrin ether(DHE)的阴离子基DHE~(?)的生成与[O_2]的关系。结果表明,空气饱和条件DHE光敏反应生成~1O_2的同时还伴有DHE~(?)的
Since the hypoxic condition of tumor is not conducive to the generation of ~ 10 O2 and · OH in phototoxic cancer cells, the idea that Moan et al. Proposed that anion radical of photosensitizer may have an effect on cancer cells is of great significance. To explore the mechanism of the above action, we must first understand the relationship between anion generation and oxygen. To this end, ESR method was used to study the anion radical DHE ~ 2 of dihydroporphyrin ether (DHE), which is the active component of photofrin Ⅱ, (?) Generation and [O_2] relationship. The results show that the DHE ~ (?) - induced DHE ~