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目的:比较复方龟鹿颗粒剂与膏剂对老龄小鼠的抗氧化作用。方法:将老龄小鼠随机分成阴性对照组、阳性对照组、治疗组,测定连续给药18d后对老龄小鼠红细胞中的超氧化物歧化酶(SOD)和心肌过氧化脂质(LPO)的影响。结果:复方龟鹿颗粒和膏剂均能明显提高老龄小鼠红细胞中SOD含量(P<0.01),显著降低老龄小鼠心肌LPO的含量(P<0.01)。结论:复方龟鹿颗粒剂同膏剂一样具有明显的抗氧化作用。
Objective: To compare the anti-oxidation effects of Compound Guilu Granules and ointment on old mice. METHODS: Older mice were randomly divided into negative control group, positive control group, and treatment group. The levels of superoxide dismutase (SOD) and myocardial lipid peroxide (LPO) in red blood cells of aged mice were determined after 18 days of continuous administration. influences. RESULTS: Compound Guilu Granules and ointment could significantly increase the content of SOD in red blood cells of aged mice (P<0.01), and significantly reduced the myocardial LPO content in old mice (P<0.01). Conclusion: Compound Guilu granules have the same antioxidant effect as ointment.