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目的探讨血管内皮生长因子(VEGF)及胎盘蛋白-14(PP-14)在子宫内膜异位症诊断中的价值及临床意义。方法分析在医院接受治疗的36例子宫内膜异位症患者的临床资料并列为观察组,同时选取41例在医院进行健康检查的正常妇女作为对照组,检测两组妇女血清VEGF、PP-14水平,并分析子宫内膜异位症患者的VEGF与PP-14的相关性。结果观察组患者血清VEGF、PP-14水平明显高于对照组,差异有统计学意义(P<0.05)。III+IV期EM患者血清VEGF、PP-14水平明显高于I+II期EM患者,差异有统计学意义(P<0.05)。观察组患者VEGF与PP-14呈现显著正相关(r=0.642,P<0.01);PP-14诊断特异性高于VEGF(χ2=4.126,P<0.05),二者在诊断敏感性水平上差异无统计学意义(χ2=0.563,P>0.05)。结论 VEGF、PP-14可作为子宫内膜异位症患者诊断的敏感性指标,其表达水平与子宫内膜异位症严重程度有关,均具有一定的临床诊断价值。
Objective To investigate the value and clinical significance of vascular endothelial growth factor (VEGF) and placental protein-14 (PP-14) in the diagnosis of endometriosis. Methods The clinical data of 36 patients with endometriosis who were treated in the hospital were selected as the observation group and 41 healthy women in the hospital were selected as the control group. Serum levels of VEGF, PP-14 Level, and analysis of VEGF and PP-14 in patients with endometriosis. Results The levels of serum VEGF and PP-14 in the observation group were significantly higher than those in the control group (P <0.05). The levels of serum VEGF and PP-14 in stage III + IV EM patients were significantly higher than those in stage I + II EM patients (P <0.05). There was a significant positive correlation between VEGF and PP-14 in the observation group (r = 0.642, P <0.01). The diagnostic specificity of PP-14 was higher than VEGF (χ2 = 4.126, P <0.05) No statistical significance (χ2 = 0.563, P> 0.05). Conclusions VEGF and PP-14 can be used as diagnostic markers in patients with endometriosis. The expression levels of VEGF and PP-14 are related to the severity of endometriosis, all of which have certain clinical diagnostic value.