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低肽在生物体内具有各种生物功能.它们能与生命金属元素相结合与代谢,也能与外界摄入的毒性金属如Cd(Ⅱ)、Ni(Ⅱ)等相结合.但是迄今,人们还不能圆满地解释毒性金属对人体的影响,这在很大程度上是由于研究金属-蛋白质络合物具有一定的困难.基于这一原因,人们常用低肽作为模型物质研究金属与蛋白质的相互作用.一般来说,二肽具有三个可供键合的位置:N端氨基、C端羧基和肽键.在生理条件下,有关简单的二肽与Ni(II)、Cd(II)络合物生成的研究为数不多.
Low peptides have a variety of biological functions in living organisms, which can bind to and metabolize vital metal elements, and can also bind to toxic metals such as Cd (II), Ni (II) and the like which are ingested outside the body, but so far, The in vivo effects of toxic metals can not be satisfactorily explained, in large part because of the difficulties associated with studying metal-protein complexes, and for this reason, low-peptides are often used as model materials to study metal-protein interactions In general, the dipeptide has three positions available for attachment: the N-terminal amino group, the C-terminal carboxyl group and the peptide bond Under physiological conditions, the simple dipeptide complexed with Ni (II), Cd (II) There are only a few studies on genesis.