绒促性素(Human Chorionic Gonadotrophin,HCG)是人胎盘滋养层分泌的一种糖蛋白类促性腺激素,由92个氨基酸残基组成的α亚基和由145个氨基酸残基组成的β亚基以非共价键连接而成[1]。HCG的药理作用主要是对雌性能促使卵泡成熟及排卵,并使破裂卵泡转变为黄体,促使其分泌孕激素,对雄性则具有促间质细胞激素的作用,特别是睾丸间质细胞的活动,使其产生雄激素,促使性器官和副性征发育及成熟等[2]。绒促性素生物测定法是绒促性素及其制剂控制质量的重要检查项目,各国药典根据HCG可以促性 Human Chorionic Gonadotrophin (HCG), a glycoprotein gonadotropin secreted by the human placental trophoblast, consists of a 92-residue alpha subunit and a 145-residue beta subunit Non-covalent bond formed [1]. The pharmacological action of HCG is mainly on the female to promote follicular maturation and ovulation, and the ruptured follicles into the corpus luteum, prompting its secretion of progesterone, the male has the role of mesangiogens, especially the activity of testicular stromal cells, To produce androgen, prompting sexual organs and secondary sexual signs of development and maturity [2]. Villus gonadotropin bioassay is a cashmere hormone and its preparation quality control important inspection items, according to the national pharmacopoeia HCG can promote