为了确定磺脲类药物和外源性胰岛素,在对胰岛素作用上是否有不同的效应,作者对8例(男1,女7)非胰岛素依赖型糖尿病者(NIDD)进行了随机交叉研究。其中2例为新发,余6例病程自2个月至8年。试验前3周停用一切药物。试验期开始3周单纯饮食控制(糖50％,脂肪30％,蛋白15％),然后随机分为两组,一组用甲磺氮草脲(tolazamide)每日服1～2次,根据血糖调整剂量,最多不超过1.5g/d;另一组用胰岛素锌混悬液(lente insulin)每日注射2次治疗。3个月后两组互换使用药物,再用药3个 To determine whether sulfonylureas and exogenous insulin have different effects on insulin action, the authors randomized 8 patients (male 1, female 7) with non-insulin-dependent diabetes mellitus (NIDD) to randomized crossover study. Two cases were newly diagnosed, and the remaining 6 cases ranged from 2 months to 8 years. 3 weeks before the trial to disable all drugs. Three weeks after the beginning of the test period, dietary control (50% sugar, 30% fat, 15% protein) was started and then randomly divided into two groups. One group received tolazamide once or twice a day, The dose was adjusted to not more than 1.5g / d; the other group was injected twice daily with lente insulin. Three months after the two groups use drugs interchangeably, and then medication 3