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目的探讨男性尖锐湿疣(CA)现症患者的固定异性性伴侣宫颈人乳头瘤病毒(HPV)的感染情况,以及使用光动力疗法治疗HPV亚临床感染及潜伏感染的疗效。方法检测男性CA现症患者的固定未发病异性性伴侣(观察组)的宫颈HPV感染情况,与健康体检妇女人群(健康体检组)对照。将观察组中发现的HPV阳性的病例随机分为治疗组和对照组,治疗组给予光动力治疗,观察CA的发病率和HPV的转阴率;对照组定期随访。结果入选观察组病例共120例,子宫颈HPV感染发生率为58.33%,与健康体检组(4.55%)比较差异有统计学意义(χ2=75.558,P<0.05)。治疗组通过光动力治疗,CA发病率为5.71%,较对照组(34.29%)低,差异有统计学意义(χ2=8.929,P<0.05);治疗组HPV转阴率为85.71%,对照组为5.71%,差异均有统计学意义(χ2=54.914,P<0.05)。结论对男性CA患者的固定性伴侣进行早期监测和干预,能有效预防CA的发生,对控制性传播疾病的蔓延及宫颈癌的发生具有重要意义。
Objective To investigate the infection of immobilized heterosexual cervical HPV in male patients with condyloma acuminatum (CA) and the therapeutic effect of photodynamic therapy on subclinical HPV infection and latent infection. Methods Cervical HPV infection was detected in non-infected male heterosexual couples (observation group) with male CA patients and compared with healthy women (healthy group). The HPV-positive cases found in the observation group were randomly divided into treatment group and control group. The treatment group was given photodynamic therapy. The incidence of CA and the negative conversion rate of HPV were observed. The control group was followed up regularly. Results A total of 120 patients were enrolled in the observation group. The incidence of cervical HPV infection was 58.33%, which was significantly different from that of the healthy group (χ2 = 75.558, P <0.05). In the treatment group, the incidence of CA was 5.71%, which was lower than that of the control group (34.29%), the difference was statistically significant (χ2 = 8.929, P <0.05). In the treatment group, the HPV negative conversion rate was 85.71% Was 5.71%, the differences were statistically significant (χ2 = 54.914, P <0.05). Conclusion Early monitoring and intervention of fixed partners in male patients with CA can effectively prevent the occurrence of CA, which is of great significance for the control of the spread of sexually transmitted diseases and the occurrence of cervical cancer.