对7例严重心力衰竭患者应用国产甲腈利酮治疗,采用有创性检查观察血流动力学效应。发现用药后半小时心排指数增加46.48％,肺毛细血管楔嵌压下降34.07％,外周血管和肺血管阻力分别下降34.59％和45.22％,血压和心率变化不大。未见明显不良反应。初步结果提示国产甲腈利酮可能成为治疗严重心力衰竭有前途的新药。 7 cases of severe heart failure patients with domestic nitrile treatment, the use of invasive examination to observe the hemodynamic effect. Half a hour after treatment, the index of cardiac index increased 46.48%, pulmonary capillary wedge pressure decreased 34.07%, peripheral vascular and pulmonary vascular resistance decreased 34.59% and 45.22% respectively, with little change of blood pressure and heart rate. No obvious adverse reactions. The preliminary results suggest that domestic nitrilone may be a promising new drug for the treatment of severe heart failure.