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目的观察胎盘多肽注射液在Ⅱ~Ⅲ期胃癌化疗中的减毒作用。方法选择2010年10月至2012年6月间住院治疗的82例胃癌患者,术后病理证实Ⅱ期、Ⅲ期。随机分为试验组(胎盘多肽注射液联合化疗)41例和对照组(单纯化疗)41例。化疗方案均选用FOLFOX6方案,试验组在FOLFOX6方案化疗的基础上加用胎盘多肽注射液8 ml,每天1次,静脉滴注,连用10d,伴随每个化疗周期。2个周期后评价血液学毒性、自然杀伤(NK)细胞活性及乏力症状积分。结果试验组患者白细胞减少程度、中性粒细胞减少程度及乏力症状积分明显低于对照组(P<0.05),试验组NK细胞活性明显高于对照组,而在贫血程度和血小板减少程度方面,两组差异无统计学意义(P>0.05)。结论胎盘多肽注射液能明显减轻Ⅱ~Ⅲ期胃癌患者化疗所致的不良反应情况。
Objective To observe the attenuating effect of placental peptide injection in chemotherapy of stage Ⅱ ~ Ⅲ gastric cancer. Methods Eighty-two cases of gastric cancer hospitalized in our hospital from October 2010 to June 2012 were selected. Pathology confirmed stage Ⅱ and stage Ⅲ. Randomly divided into experimental group (placental peptide injection combined with chemotherapy) 41 cases and control group (chemotherapy alone) 41 cases. The chemotherapy regimens used FOLFOX6 regimen. The experimental group added 8 ml of placental peptide injection on the basis of FOLFOX6 chemotherapy once daily, intravenously for 10 days, with each chemotherapy cycle. Hematological toxicity, natural killer (NK) cell activity and fatigue symptom scores were evaluated after 2 cycles. Results The leukopenia, neutropenia and fatigue symptom scores in the experimental group were significantly lower than those in the control group (P <0.05). The NK cell activity in the experimental group was significantly higher than that in the control group, while in the degree of anemia and thrombocytopenia, There was no significant difference between the two groups (P> 0.05). Conclusion Placental peptide injection can significantly reduce the adverse reactions caused by chemotherapy in patients with stage Ⅱ ~ Ⅲ gastric cancer.