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心房颤动(简称房颤)是临床上最为常见的心律失常,具有高致残率和高致死率特点~[1]。微小RNA(microRNA,miRNA)是新发现的一类高度保守的内源性非编码小RNA,是基因表达转录后调节的重要分子,能够通过与靶mRNA特异性的碱基配对引起靶mRNA的降解或者抑制其翻译,从而对基因进行转录后表达的调控~[2]。miRNA通过对编码心房肌电重构与结构重构基因调节,参与房颤的发生与维持。而房颤时发生心房结构重构机制可能包括:心房肌局部肾素-血管紧张素系统
Atrial fibrillation (referred to as atrial fibrillation) is the most common clinical arrhythmia, with high morbidity and high mortality characteristics of ~ [1]. MicroRNAs (miRNAs) are a newly discovered class of highly conserved, endogenous, non-coding small RNAs that are important posttranscriptional regulators of gene expression that cause target mRNA degradation through base-specific base pairing with target mRNAs Or inhibit its translation, thereby regulating the transcription of the gene expression ~ [2]. MiRNAs are involved in the occurrence and maintenance of atrial fibrillation by regulating the electrical and structural remodeling of atrial myocytes. Atrial structural remodeling mechanisms during atrial fibrillation may include: atrial local renin-angiotensin system