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目的:研究米氮平结合帕潘立酮治疗脑梗死合并抑郁焦虑症的临床效果。方法:选择进行治疗的脑梗死合并抑郁焦虑症患者90例,按随机分组原则将其分为观察组和对照组,对照组给予常规降血压药物配合心理疏导进行治疗,观察组在常规治疗的基础上加用米氮平联合帕潘立酮进行治疗,4周为1个疗程,1个疗程后,通过对比两组患者焦虑抑郁程度和血压改善状况进行评价。结果:观察组患者降压疗效总有效率为91.11%(41/45),明显高于对照组的73.33%(33/45),观察组抗抑郁疗效总有效率为93.56%(41/45),明显高于对照组85.65%(34/45),差异均有统计学意义(P<0.05)。观察组有2例(4.4%)患者出现嗜睡,1例(2.2%)出现头痛、恶心,2例(4.4%)出现体重增加,随着治疗继续,逐渐恢复正常。结论:米氮平结合帕潘立酮治疗脑梗死合并抑郁焦虑症能够有效降低患者的焦虑程度,改善患者血压状态,建议在临床上推广应用。
Objective: To study the clinical effect of mirtazapine and paliperidone in treating cerebral infarction with depression and anxiety. Methods: Ninety patients with cerebral infarction and depression-related anxiety were selected and divided into observation group and control group according to the principle of randomization. The control group was treated with routine antihypertensive drugs and psychological counseling. The observation group was treated on the basis of routine treatment Addition of mirtazapine combined with paliperidone for treatment, 4 weeks for a course of treatment, after a course of treatment, by comparing the two groups of patients with anxiety and depression and blood pressure to improve the status of evaluation. Results: The total effective rate of antihypertensive effect in observation group was 91.11% (41/45), significantly higher than that in control group (73.33%, 33/45). The total effective rate of antidepressant effect in observation group was 93.56% (41/45) , Which was significantly higher than that of the control group (85.65%, 34/45), the differences were statistically significant (P <0.05). In the observation group, 2 patients (4.4%) developed drowsiness, 1 had headache and nausea (2.2%), 2 gained weight (4.4%), and returned to normal as the treatment continued. Conclusion: The combination of mirtazapine and paliperidone in the treatment of cerebral infarction with depression and anxiety can effectively reduce the level of anxiety and improve the blood pressure of patients. It is suggested that it should be widely applied in clinic.