本文用计算机构建了电压门控型钾离子通道孔区的一种结构模型。根据构建的模型，Ｓｈａｋ－ｅｒＢ的Ｇｌｙ４４４和Ｇｌｙ４４６的主链羰基氧形成了孔区最窄的部分；通道的离子选择性是通过氧笼机理来实现的；残基４４７，４４８，４４９构成了毗邻最窄区的孔外侧入口；ＴＥＡ就是通过与４４９和４４７残基相互作用阻塞了这个入口从而阻断离子通道的。我们构造的模型与许多已知的实验事实相吻合。 In this paper, a structural model of voltage-gated K + channel region has been constructed by computer. Based on the model constructed, the backbone carbonyl oxygen of ShaL-erB’s Gly444 and Gly446 formed the narrowest pore region; the ion selectivity of the channel was achieved by the oxygen cage mechanism; residues 447, 448, 449 formed the adjacent The narrowest outer entrance to the pore; TEA blocks the ion channel by blocking this entry by interacting with residues 449 and 447. The model we constructed coincides with many known experimental facts.