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目的研究在肝炎分型诊断过程中检测血清5’-NT浓度的临床应用价值。方法选择200例肝炎患者进行研究,选择同期50例健康者,采血检测血清GGT、ALP、ALT、AST以及5’-NT浓度进行对比分析。结果对所有受试人员血清GGT、ALP、ALT、AST及5’-NT浓度进行检测,发现健康者人群的各项肝酶浓度与5’-NT浓度显著低于急慢性肝炎、重型肝炎以及肝炎肝硬化患者,差异有统计学意义(P<0.05)。其中急性肝炎患者血清5’-NT浓度显著高于慢性肝炎(P<0.05),重型肝炎患者血清5’-NT浓度显著高于肝炎肝硬化(P<0.05)。结论血清5’-NT是临床肝炎诊断中重要生化检查项目,具有高敏性,临床应该结合常规肝功能指标进行联合检测,对鉴别肝炎分型方面具有重要指导意义。
Objective To study the clinical value of serum 5’-NT in the diagnosis of hepatitis. Methods 200 cases of hepatitis patients were selected to study, select the same period 50 healthy subjects, serum GGT, ALP, ALT, AST and 5’-NT concentrations were compared. Results Serum concentrations of GGT, ALP, ALT, AST and 5’-NT in all subjects were detected. The concentrations of liver enzymes and 5’-NT in healthy subjects were significantly lower than those of acute and chronic hepatitis, severe hepatitis and hepatitis The difference was statistically significant in patients with cirrhosis (P <0.05). The concentration of serum 5’-NT in patients with acute hepatitis was significantly higher than that in patients with chronic hepatitis (P <0.05). The serum 5’-NT level in patients with severe hepatitis was significantly higher than that in hepatitis with cirrhosis (P <0.05). Conclusion Serum 5’-NT is an important biochemical test in the diagnosis of clinical hepatitis. It has high sensitivity and should be combined with routine liver function tests in clinical practice. It has important guiding significance in differentiating hepatitis typing.