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目的评价89SrCl2对老年患者前列腺癌骨转移伴骨痛的临床疗效及不良反应。方法对外科去势治疗术后的老年患者前列腺癌骨转移伴有不同程度骨痛患者48例,使用89SrCl2静脉注射治疗,观察其镇痛效果、骨转移灶的变化、前列腺特异性抗原(PSA)及不良反应等。结果48例患者接受89Sr治疗后,止痛的总有效率达89·6%,无效10·4%,骨转移灶有明显减少。对PSA有不同程度的下降。所有治疗者均未发现严重的不良反应和毒副作用。结论89SrCl2对去势治疗术后的老年患者前列腺癌骨转移骨痛的临床止痛疗效明显,特别是对多发骨转移癌伴骨痛患者是一种有效的治疗方法。
Objective To evaluate the clinical efficacy and adverse reactions of 89SrCl2 on bone metastasis of prostate cancer with bone pain in elderly patients. Methods Forty-eight patients with bone metastasis of prostate cancer were treated with 89SrCl2 intravenous injection. The analgesic effects, the changes of bone metastases, the changes of prostate-specific antigen (PSA) And adverse reactions. Results 48 patients received 89Sr treatment, the total effective rate of analgesic was 89.6%, ineffective 10.4%, bone metastases were significantly reduced. PSA to varying degrees of decline. No serious adverse reactions and side effects were found in all the patients. Conclusion 89SrCl2 has obvious curative effect on clinical analgesia of bone metastasis of prostate cancer in elderly patients after castration therapy. It is an effective treatment for patients with multiple bone metastases and bone pain.