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目的 研究 p2 7Kip1 表达与乳癌生物学行为的关系及对预后的影响。方法 采用免疫组织化学方法检测 51例乳腺浸润性导管癌组织p2 7表达水平 ,对其与乳癌临床病理特征和术后生存时间的关系进行了分析。结果 51例中 ,p2 7高表达者 1 8例 ,占 35 .3 % ;低表达者 33例 ,占 64 .7%。p2 7表达水平与肿块大小、腋淋巴结状态、TNM分期、组织学分级、复发和转移可能有关 ;p2 7高表达组术后 5年生存率高于低表达组。结论 p2 7表达水平与乳癌的发生、发展有一定关联 ,可作为判断预后的参考指标。
Objective To study the relationship between the expression of p27Kip1 and the biological behavior of breast cancer and the prognosis. Methods Immunohistochemistry was used to detect the expression of p27 protein in 51 cases of invasive ductal carcinoma of the breast. The relationship between the expression of p27 and the clinicopathological characteristics of breast cancer and the postoperative survival time were analyzed. Results Among the 51 cases, 18 cases were highly expressed in p27, accounting for 35.3%; 33 cases were low expression, accounting for 64.7%. The expression level of p27 was related to tumor size, axillary lymph node status, TNM stage, histological grade, recurrence and metastasis. The 5-year survival rate of p27 high expression group was higher than that of low expression group. Conclusions The expression level of p27 correlates with the occurrence and development of breast cancer and may be used as a reference index for prognosis.