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目的了解糖尿病(DM)和糖尿病足(DF)感染患者的维生素D(Vitamin D,Vit D)水平,及两者的维生素D缺乏情况,探讨维生素D对糖尿病足感染患者的影响。方法收集2015年1-4月温州医科大学附属第一医院内分泌科住院糖尿病患者120例,按有无合并足部感染,分为糖尿病足感染患者60例,设为DF组,糖尿病无合并感染患者60例,设为DM组,同时收集非糖尿病健康体检者60例,设为对照组,回顾性分析3组的25羟基维生D[25 hydroxy vitamin D,25(OH)Vit D]、糖化血红蛋白(Hb A1C)、C反应蛋白、血白细胞计数和血沉等指标。结果 DM组、DF组25(OH)Vit D水平低于对照组,Hb A1C高于对照组,差异均有统计学意义(P<0.05)。DF组C反应蛋白、血白细胞计数和血沉水平高于对照组,差异均有统计学意义(P<0.05)。DM组发生维生素D缺乏[25(OH)Vit D<50 nmol/L]风险较对照组增加[OR=1.3(95%CI:0.6~2.7),P=0.016],DF组发生维生素D缺乏风险较对照组明显增加[OR=3.2(95%CI:1.5~6.8),P=0.018];DF组发生严重维生素D缺乏的风险较DM组明显升高[OR=3.0(95%CI:1.3~6.8),P=0.032]。结论糖尿病、糖尿病足感染患者的25(OH)Vit D水平下降,维生素D缺乏与糖尿病、糖尿病足感染发生相关。
Objective To investigate the levels of vitamin D (Vit D) in both diabetic (DM) and diabetic foot (DF) infected patients and their vitamin D deficiency, and to explore the impact of vitamin D on diabetic foot infections. Methods A total of 120 diabetic inpatients with endocrinology in the First Affiliated Hospital of Wenzhou Medical University from January to April in 2015 were enrolled in this study. They were divided into diabetic foot infection group (60 cases) and DF group Sixty patients were randomly divided into DM group and 60 healthy subjects without diabetes. All the patients were enrolled as control group. The 25 25-hydroxy vitamin D (25 (OH) Vit D], glycosylated hemoglobin (Hb A1C), C-reactive protein, white blood cell count and erythrocyte sedimentation rate and other indicators. Results The levels of 25 (OH) Vit D in DM group and DF group were lower than those in control group and Hb A1C was higher than that in control group (P <0.05). The levels of C-reactive protein, white blood cell count and erythrocyte sedimentation rate in DF group were significantly higher than those in control group (P <0.05). In the DM group, the risk of vitamin D deficiency [25 (OH) Vit D <50 nmol / L was higher in the DM group than in the control group [OR = 1.3 (95% CI 0.6-2.7, P = 0.016] (95% CI: 1.5-6.8, P = 0.018). The risk of severe vitamin D deficiency in DF group was significantly higher than that in DM group [OR = 3.0 (95% CI: 6.8), P = 0.032]. Conclusion The levels of 25 (OH) Vit D in patients with diabetic and diabetic foot infections are decreased, while the vitamin D deficiency is associated with the occurrence of diabetic foot and diabetic foot infections.