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为研究组织蛋白酶－D（Cath－D）和CD44表达与喉癌临床、病理和预后的关系，采用免疫组织化学方法检测Cath－D和CD44在96例喉鳞状细胞癌中的表达情况。结果显示，Cath－D和CD44在喉癌中表达的阳性率分别为52．1％和41．7％；Cath－D的阳性表达与喉癌转移（包括颈淋巴结转移和远处转移）呈正相关，但单独与颈淋巴结转移无关，CD44表达与转移无关；另外，Cath－D和CD44表达与喉癌分期、细胞的病理分级、肿瘤大小和术后3年生存率均无关。提示，Cath－D在喉癌发生转移过程中可能起到一定作用。
To investigate the relationship between the expression of cathepsin-D (Cath-D) and CD44 and the clinical, pathological and prognosis of laryngeal carcinoma, the expression of Cath-D and CD44 in 96 cases of laryngeal squamous cell carcinoma was detected by immunohistochemistry. The positive rates of Cath-D and CD44 expression in laryngeal carcinoma were 52.1% and 41.7% respectively. The positive expression of Cath-D was positively correlated with the metastasis of laryngeal carcinoma (including cervical lymph node metastasis and distant metastasis) , But no correlation was found between the expression of CD44 and the metastasis of cervical lymph nodes. In addition, the expression of Cath-D and CD44 had no correlation with the stage of laryngeal carcinoma, the pathological grade of tumor, the tumor size and the 3-year survival rate. Tip, Cath-D in the metastasis of laryngeal carcinoma may play a role.