概论 药物与肝脏的关系颇为密切,主要因药物进入人体后,必须通过肝脏内3个步骤:(1)肝细胞摄取药物;(2)药物在肝内代谢;(3)药物在胆道系统中排泄.其中以肝脏内药物代谢时,肝脏微粒体内混合功能氧化酶(细胞色素P_(450))所起的影响最大,它可使药物的药理作用降低或缩短,但亦可在脂溶性化合物转变为水溶性化合物时,产生对肝脏有高度反应性的有毒代谢产物. Introduction The relationship between drugs and the liver is quite close, mainly due to the drug into the human body, you must pass the liver in three steps: (1) liver cell uptake of drugs; (2) drug metabolism in the liver; (3) drugs in the biliary system Excretion of liver drug metabolism, liver microsomal mixed function oxidase (cytochrome P_ (450)) the greatest impact, it can reduce or shorten the pharmacological effects of drugs, but also in fat-soluble compounds change Is a water-soluble compound that produces toxic metabolites that are highly reactive with the liver.