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丁尿胺[或称丁苯氧酸(Bumetanide),即3-丁氨基-4-苯氧基-5-氨磺酰基苯甲酸]与速尿(Frusemide)一样,也是一种强效袢利尿药,桂林制药厂已研制投产。国外文献大多认为,丁尿胺与速尿的利尿作用约为40:1;即在一般情况下,1mg丁尿胺的利尿效果约相当于40 mg的速尿。为了评价国产丁尿胺的利尿效果,我们对正常人、水肿病人和慢性肾功能衰竭病人分别用丁尿胺和速尿进行了利尿作用比较,现报告如下。方法按1 mg丁尿胺与40 mg速尿的比例进行比较。 1.正常人:选择7名健康成人,18～47岁,4男3女。试验前照常活动进食。试验日上午6时排尽尿弃去,然后每小时饮水100 ml(内含Na~+15 mmol/l,K~+4 mmol/l),进食馒头0.75～1.5两(按每人平时食量而定,每次食量固定不变)并排尿一次,共2～3次,记录对照期平均尿量。上午9时饮水100 ml后解尿并口服丁尿胺1 mg(片剂1片),不吃馒头,以免食物影响药
Butylamine [or Bumetanide, also known as Frusemide, is also a potent [...] diuretic Guilin Pharmaceutical Factory has been put into operation. Most foreign literature that the diuretic and furosemide diuretic effect of about 40: 1; that is, under normal circumstances, 1mg of buccal amine diuretic effect is equivalent to 40 mg of furosemide. In order to evaluate the diuretic effect of domestic buttermilk, we compared the diuretic effects of buthinamide and furosemide on normal, edematous patients and chronic renal failure patients, respectively, and are reported as follows. Methods 1 mg of butylamine and 40 mg of furosemide were compared. 1. Normal: choose seven healthy adults, 18 to 47 years old, 4 men and 3 women. As usual activity before eating test. The test day at 6 o’clock in the morning drained to discard, and then drink 100 ml per hour (containing Na ~ +15 mmol / l, K ~ +4 mmol / l), eating steamed bread 0.75 to 1.5 two Set, each appetite fixed) and urination once, a total of 2 to 3 times, record the average urine volume during the control period. 9:00 am drinking water after 100 ml urine and oral 1 mg of buccal amine (tablet 1), do not eat bread, so food is not affected by medicine