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目的探讨2型糖尿病对急性脑梗死发生阿司匹林抵抗的影响。方法选取江门市人民医院120例急性脑梗死患者作为研究对象,根据有无糖尿病分为两组,对两组患者均给予拜阿司匹林治疗,服用后检测两组患者血小板聚集率以及阿司匹林抵抗(AR)发生率与阿司匹林半抵抗(ASR)发生率。结果合并糖尿病组花生四烯酸诱导下及二磷酸腺苷诱导下血小板聚集率分别为(67.9±8.5)%、(77.4±10.5)%,较未合并糖尿病组有明显上升,差异有统计学意义(P<0.01);合并糖尿病组患者的AR、ASR发生率分别为30.61%、38.78%,较未合并糖尿病组有明显升高,差异有统计学意义(P<0.05)。结论急性脑梗死患者合并2型糖尿病后AR、ASR发生率明显上升,故临床应重视对糖尿病患者血糖的监控,定期监测血小板聚集率。
Objective To investigate the effect of type 2 diabetes on aspirin resistance in acute cerebral infarction. Methods A total of 120 acute cerebral infarction patients from Jiangmen Municipal People’s Hospital were enrolled in this study. Patients were divided into two groups according to their diabetes mellitus. Both groups were treated with aspirin. The platelet aggregation rate and aspirin resistance (AR) Incidence and aspirin half-resistance (ASR) incidence. Results The platelet aggregation rate induced by arachidonic acid and adenosine diphosphate was (67.9 ± 8.5)% and (77.4 ± 10.5)%, respectively in diabetic patients with diabetes mellitus, which were significantly higher than those in non-diabetic patients (P <0.01). The incidences of AR and ASR in patients with diabetes mellitus were 30.61% and 38.78%, respectively, which were significantly higher than those in non-diabetic patients (P <0.05). Conclusion The incidence of AR and ASR in patients with acute cerebral infarction after type 2 diabetes mellitus is significantly increased. Therefore, the blood glucose monitoring in diabetic patients should be emphasized and the platelet aggregation rate should be monitored regularly.