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目的探讨99mTc-HL91乏氧显像诊断脑胶质瘤及预测其恶性程度的临床价值。方法32例确诊的脑胶质瘤患者(其中低度恶性9例,高度恶性23例)和20例正常对照组行99mTc-HL91乏氧显像,对早期(15min)显像和延迟(3h)显像结果进行定性和半定量分析。并对低度恶性组和高度恶性组的半定量分析结果进行比较。结果:99mTc-HL91乏氧显像诊断脑胶质瘤的灵敏度、特异性和准确率分别是81.3%(26/32)、100%(20/20)和88.5%(46/52)。其中高度恶性组阳性显像率为100%(23/23),低度恶性组阳性显像率为33.3%(3/9)。早期和延迟显像半定量分析结果高度恶性组摄取99mTc-HL91明显高于低度恶性组。结论:99mTc-HL91乏氧显像应用于诊断脑胶质瘤并预测其恶性程度具有较高的临床价值。
Objective To investigate the clinical value of 99mTc-HL91 hypoxia imaging in the diagnosis of gliomas and to predict its malignancy. Methods Thirty-two patients with gliomas diagnosed as glioma (including 9 with low grade of malignancy and 23 with high grade of malignancy) and 20 normal controls were performed 99mTc-HL91 hypoxic imaging. Imaging results were qualitative and semi-quantitative analysis. The results of semi-quantitative analysis were compared between the low-grade group and the high-grade group. Results: The sensitivity, specificity and accuracy of 99mTc-HL91 hypoxia imaging in diagnosing gliomas were 81.3% (26/32), 100% (20/20) and 88.5% (46/52), respectively. Among them, the positive imaging rate was 100% (23/23) in high malignant group and 33.3% (3/9) in low malignant group. Semi-quantitative analysis of early and delayed imaging results showed that 99mTc-HL91 was significantly higher in the malignant group than in the low-grade malignant group. Conclusion: The application of 99mTc-HL91 hypoxia imaging in the diagnosis of gliomas and prediction of its malignancy has high clinical value.