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目的研究异常妊娠孕妇外周血中胎儿有核红细胞的数量变化。方法富集孕妇外周血中胎儿有核红细胞后计数,再用PEP-PCR技术鉴别其来源。比较中孕期妊高征组、胎儿畸形组、死胎组与正常妊娠组孕妇外周血中胎儿有核红细胞的数量有无差异。结果3组异常妊娠样本中的胎儿有核红细胞的数量均明显高于正常妊娠组(P<0.05)。3组异常妊娠组的胎儿有核红细胞数量之间无明显差异(P>0.05)。结论发生妊高征、胎儿畸形与死胎的孕妇外周血中胎儿有核红细胞的数量异常升高,起一定的标志作用。
Objective To study the changes of fetal nucleated erythrocytes in peripheral blood of pregnant women with abnormal pregnancy. Methods Fetal nucleated erythrocytes were enriched in peripheral blood of pregnant women, and their origin was identified by PEP-PCR. Pregnancy compared with pregnancy induced hypertension group, fetal malformation group, stillbirth group and normal pregnancy group of pregnant women with fetal nucleated blood cells in the number of whether there is any difference. Results The number of fetal nucleated erythrocytes in abnormal pregnancy samples was significantly higher than that in normal pregnancy group (P <0.05). There was no significant difference in the number of fetal erythrocytes between the three groups of abnormal pregnancy (P> 0.05). Conclusions The number of fetal erythrocytes in peripheral blood of pregnant women with PIH, fetal malformations and stillbirth is abnormally elevated, which plays a role as a marker.